2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

Related Products

PDF 38.29 MB

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140343
    Ac4GalNAl 1673590-09-4 99.78%
    Ac4GalNAl is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. Ac4GalNAl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Ac4GalNAl
  • HY-133323
    m-PEG24-acid 2248203-61-2 99.91%
    m-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG24-acid
  • HY-W096067
    Benzyl-PEG7-alcohol 423763-19-3
    Benzyl-PEG7-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG7-alcohol
  • HY-140233
    Boc-amido-PEG9-amine 890091-43-7 ≥98.0%
    Boc-amido-PEG9-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-amido-PEG9-amine
  • HY-140342
    Boc-C16-NHS ester 843666-34-2 98.0%
    Boc-C16-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-C16-NHS ester
  • HY-136140
    Aldehyde-benzyl-PEG5-alkyne 1378928-83-6
    Aldehyde-benzyl-PEG5-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Aldehyde-benzyl-PEG5-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Aldehyde-benzyl-PEG5-alkyne
  • HY-42489
    N3-PEG3-CH2CH2-Boc 252881-73-5 98.0%
    N3-PEG3-CH2CH2-Boc is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N3-PEG3-CH2CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. N3-PEG3-CH2CH2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N3-PEG3-CH2CH2-Boc
  • HY-140330
    (10-BRomodecyl)phosphonic acid 934985-98-5 99.44%
    (10-BRomodecyl)phosphonic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    (10-BRomodecyl)phosphonic acid
  • HY-126881
    Fmoc-PEG2-C2-NHS ester 1807534-85-5 98.89%
    Fmoc-PEG2-CH2CH2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-PEG2-C2-NHS ester
  • HY-W009037
    Maleimide-C10-NHS ester 87981-04-2 98.0%
    Maleimide-C10-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Maleimide-C10-NHS ester
  • HY-140619
    DNP-PEG4-DBCO 2149585-17-9
    DNP-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DNP-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DNP-PEG4-DBCO
  • HY-140903
    Biotin-PEG4-TFP ester 2985664-57-9
    Biotin-PEG4-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG4-TFP ester
  • HY-141375
    m-PEG5-Br 854601-80-2 98.0%
    m-PEG5-Br is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG5-Br
  • HY-140847
    N-Fmoc-N'-(azido-PEG4)-L-Lysine-PFP ester 2749985-69-9
    N-Fmoc-N'-(azido-PEG4)-L-Lysine-PFP ester is an alkyl/ether and PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-Fmoc-N'-(azido-PEG4)-L-Lysine-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-Fmoc-N'-(azido-PEG4)-L-Lysine-PFP ester
  • HY-79125
    Fmoc-Hyp(Bom)-OH 187223-15-0 99.73%
    Fmoc-Hyp(Bom)-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Hyp(Bom)-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs<
    Fmoc-Hyp(Bom)-OH
  • HY-141234
    HO-PEG13-OH 17598-96-8 ≥98.0%
    HO-PEG13-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    HO-PEG13-OH
  • HY-140297
    Carboxyrhodamine 110-PEG4-DBCO
    Carboxyrhodamine 110-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Carboxyrhodamine 110-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    Carboxyrhodamine 110-PEG4-DBCO
  • HY-77593
    (2R,4S)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid 147266-92-0 98.0%
    N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    (2R,4S)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid
  • HY-W071583
    N-Boc-PEG9-alcohol 2112731-44-7 98.0%
    N-Boc-PEG9-alcohol is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG9-alcohol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    N-Boc-PEG9-alcohol
  • HY-129968
    AM-Imidazole-PA-Boc 2357108-99-5 98.22%
    AM-Imidazole-PA-Boc is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTAC IRAK4 degrader-1 (HY-129966).
    AM-Imidazole-PA-Boc
PROTAC Linkers Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.